San Francisco Giants at Chicago White Sox odds, picks and predictions

The San Francisco Giants (2-3) and the Chicago White Sox (3-3) wrap up a 3-game series Thursday. First pitch at Guaranteed Rate Field is scheduled for 2:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Series tied 1-1 in 2023. White Sox won the series 3-0 in 2022.

The Giants won the interleague series opener Monday 12-3 — an early-season high in runs. San Francisco suffered a 7-3 loss in Game 2 on Wednesday to even up the series, although the Over (7.5) cashed for a 2nd consecutive contest. San Francisco has alternated losses and wins in each of its 5 outings.

The White Sox have scored 3 or more runs in each of their 6 games while yielding 3 or more runs in each of the past 5 contests. The Over has cashed in Chicago’s last 5 contests after an Under result on Opening Day last Thursday.

Giants at White Sox projected starters

LHP Alex Wood vs. RHP Lance Lynn

Wood went 8-12 with a 5.10 ERA in 2022. He had a 1.24 WHIP, 2.1 BB/9 and 9.0 K/9 in 130 2/3 IP across 26 starts.

• Recorded a 5-7 record and 5.51 ERA with 12 HR and a .247 opponent batting average (OBA) across 67 IP in 14 road starts last season.
• Went 2-2 with a 5.95 ERA and 3 HR with 1 BB and 20 K across 19 2/3 IP in 4 interleague starts in ’22.

Lynn (0-0, 3.18) makes his 2nd start of the season. He allowed 2 ER on 3 H and 4 BB with 6 K across 5 2/3 IP in a 96-pitch debut Friday at the Houston Astros.

• Posted a 4-3 record, 4.05 ERA and .232 OBA with 9 HR allowed across 53 1/3 IP in 9 home starts in 2022.
• Allowed just 3 H and 2 BB with 5 K across 6 scoreless innings in a no-decision July 1 at San Francisco last season.

Giants at White Sox odds

BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:44 a.m. ET.

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Giants at White Sox picks and predictions

Prediction

Giants 6, White Sox 3

The GIANTS (+110) are a solid play on the road on getaway day Thursday.

The Giants are 5-1 in the past 6 games in Game 3 of a series and 12-5 in the past 17 games against a right-handed starting pitcher dating back to last season.

The White Sox are just 3-9 in the past 12 games at home dating back to last season and have cashed just once in the past 5 interleague games against a left-handed pitcher.

The Giants +1.5 (-185) are just a little too expensive in the event you need a little insurance and can’t bring yourself to play San Francisco straight up.

Chicago has dropped 3 of the past 5 games, and it has lost each of the contests by 2 or more runs.

PASS.

OVER 7.5 (-115) is worth a look in this interleague series finale.

The Over has cashed in 5 straight games for the White Sox and is 3-1 in the past 4 games for the Giants. San Francisco has cashed the Over in 9 of the past 12 games against right-handed starting pitchers dating back to last season, too.

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