Sunday Football Betting Picks: Kansas City Chiefs vs Indianapolis Colts Odds, Predictions and Best Bets

The Kansas City Chiefs and Indianapolis Colts will meet in the AFC Conference in Week 3 of the 2022 season.

Chiefs are -6.5 points with Bovada. Colts are under 21.

Kansas City Chiefs take on Indianapolis Colts on Sunday.

Kansas City Chiefs are 2-0 and the better team on both sides of the ball. Indianapolis Colts are struggling and were shutout on the road by Jacksonville. Chiefs have won 5 of their last 5 road games against a team with a losing home record.

The Chiefs defense should be able to contain Colts running back Jonathan Taylor. Colts are under 21.5 points. Under is 6-0 in Colts last 6 games vs. AFC and 7-1 in last 7 games overall.

Kansas City Chiefs are favored by 49.5 points over Indianapolis Colts. The over is 5-0 in Chiefs last 5 road games and 8-2 in their last 10 games overall.