Kansas City Chiefs vs. Indianapolis Colts odds, tips and betting trends

The Kansas City Chiefs (2-0) are the favorites against the Indianapolis Colts (0-1-2) on Sunday, September 25, 2022 at Lucas Oil Stadium. The Chiefs’ last game was against Los Angeles Chargers, and they won by a score of 27-24. Patrick Mahomes II went 24-for-35 for 235 yards with two TDs and no INTs.

Chiefs are the favorite at (-6.5) and the moneyline is (-281). The total is 49.

The Chiefs have covered the spread in a matchup one time this season. Kansas City had two wins ATS (2-1) as 6.5-point favorites or more away from home last season and has a perfect record when playing as at least 6-5 points favorites. Last year, in six of eight road games Kansas Chiefs hit the over.

The Chiefs have covered the spread in a matchup one time this season. Kansas City had two wins ATS as 6.5-point favorites or more away from home last season and has a perfect record when playing as at least 6-5 points favorites. Last year, in six of eight road games Kansas Chiefs hit the over.

Kansas City Chiefs play Indianapolis Colts on Sunday, September 25, 2022 at 1:00 PM ET at Lucas Oil Stadium.

Mahomes had 595 YDS / 297 YPG / 73% / 7 TD / 0 INT. Clyde Edwards-Helaire had 15 CARs. Isaih Pacheco had 14 CARS. Travis Kelce had 13 RECs and JuJu Smith-Schuster had 9 RECS and 44 Yds.