Titans vs. Chiefs odds, spread, line: Sunday Night Football picks, predictions by NFL model on 148-107 run

Titans vs. Chiefs is a Sunday Night Football game on KCTV5 at 8:20 p.m. ET. The winner will be in second place in the AFC and could be a tiebreaker for the playoffs. Titans quarterback Ryan Tannehill is out with an ankle injury. Kansas City is 14-point favorite. Over/under for points scored is 45. SportsLine's advanced computer model simulates every NFL game 10,000 times and has returned 148-107 straight-up wins for its clients since it was launched in 2017.

Titans vs. Chiefs is a Sunday Night Football game. Kansas City is the favorite by 14 points. Tennessee is 6-2. The Titans are the NFL's top rushing team.

Titans vs. Chiefs is Sunday Night Football. Kansas City is favored by 14 points. Tennessee is +600.

The Chiefs are one of the best offenses in the NFL. They are second in both total offense (403.3 yards per game) and passing offense. In their last game, they set season-highs in points (44) and total offence (529 yards). Andy Reid's teams are 20-3 coming off the bye week.

Titans have a formidable defensive line in Denico Autry and Jeffery Simmons. Derrick Henry is coming off his best game of the year last week. The Titans are favored by 148 points. NFL model has picked Titans to win 148-107.

SportsLine's model is leaning Over on the total and predicts the teams will combine for 49 points. One side of the spread cashes in well over 50% of simulations.