Week 10 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay returns 25-1

Matthew Stafford is in concussion protocol and could miss Sunday's game against Arizona. The Rams are 1-point favorites against the Cardinals. SportsLine's computer model simulates every NFL game 10,000 times and has made some impressive bets in the past. It has a reputation for being accurate and reliable. It is now parlaying its NFL picks for Week 10. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1.

The advanced model simulates every NFL game 10,000 times and it's high on the Tennessee Titans to cover the spread against the Denver Broncos. Quarterback Ryan Tannehill could miss his third straight game with an ankle injury and rookie Malik Willis has completed only 11-of-26 attempts in his absence. Derrick Henry has taken over the NFL rushing lead with 870 yards over his first eight games.

The model also jumped on four other NFL matchups where it says the line is way off. It's backing an underdog that has a chance to win outright.