Week 13 NFL picks, odds, 2022 best bets from advanced model: This 5-way football parlay pays out 25-1

Tennessee Titans are 7-4 and the Cincinnati Bengals are 5-5. Philadelphia Eagles are 10-1 and they beat the Green Bay Packers. The Titans lost to Cincinnati last Sunday. SportsLine's advanced computer model simulates every NFL game 10,000 times and has made over $7,500 on its NFL picks since its inception. It has now locked in five confident NFL best bets for Week 13.

The advanced model simulates every NFL game 10,000 times and it's high on the San Francisco 49ers to cover against the Miami Dolphins. San Fran is 4-1 since the acquisition of Christian McCaffrey from Carolina.

The advanced model predicts a 25-1 payout for a parlay with NFL Week 13 best bets. It also has a model with a high level of confidence that says the line is way off for four other NFL games.