Week 6 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay pays 25-1

Buffalo Bills and Kansas City Chiefs meet in a rematch at Arrowhead Stadium in the Week 6 NFL schedule. Buffalo is a 3-point favorite. SportsLine's advanced computer model simulates every NFL game 10,000 times and has made 146-106 straight-up NFL picks since 2017. It has also nailed five NFL parlays for Week Six. It is up almost $7,100 for $100 players on top-rated NFL bets since its inception.

The model simulates every game 10,000 times and it's picking the New York Giants to cover the spread against the Baltimore Ravens on Sunday. New Jersey has won four of its first five games this season. The Giants are tied for second in the NFC East standings after posting a 27-22 victory over Green Bay in London last Sunday and the Ravens have struggled defensively recently.

The advanced model predicts a five-way football parlay that pays 25-1. It also has a model that backs a total that is off by a full touchdown.