Week 6 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay returns 25-1

Week 6 NFL picks, odds, parlays and best bets from advanced model from SportsLine are available. Seattle Seahawks are 3-point underdogs at Caesars Sportsbook when they host Arizona on Sunday. Arizona is coming off a 20-17 loss to unbeaten Philadelphia. Sportsline's model simulates every NFL game 10,000 times and is up almost $7,00 for $100 players on top-rated NFL bets since its inception.

The advanced model simulates every NFL game 10,000 times and it's high on the New York Giants to cover against the Baltimore Ravens on Sunday. New Jersey is tied for the second-best record in the NFL through the first five weeks of the season. The Giants sprung a huge upset in London last week, shocking the Packers as 9-point underdogs.

The advanced model predicts a five-way football parlay that returns 25-1. It also backs a total that is off by a full touchdown.