Week 1 NFL picks, odds, 2023 best bets from proven model: This five-way football parlay pays 25-1
Seven divisional games are part of the Week 1 NFL schedule, highlighted by Cowboys vs. Giants on Sunday Night Football. The Cowboys have dominated this NFC East rivalry in recent years, winning nine of the last 10 meetings. According to the latest Week 1 NFL odds, Dak Prescott and the Cowboys are 3.5-point favorites over Saquon Barkley and the Giants on the road. Other divisional matchups include Bengals vs. Browns (+2), Packers vs. Bears (-1) and Rams vs. Seahawks (-4.5). Which NFL spreads should you target with your NFL bets in the league's opening week? Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.
The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2023 NFL season on an incredible 163-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-6 roll on top-rated NFL picks since Week 7 of this season.
The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has locked in five confident NFL best bets for Week 1. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 1 NFL picks at SportsLine.
Top Week 1 NFL picks
After simulating every game 10,000 times, the model is high on the San Francisco 49ers (-2.5) to cover on the road over the Pittsburgh Steelers. The 49ers are stacked with playmakers, including Christian McCaffrey, Deebo Samuel and George Kittle. San Francisco's offense averaged 365.6 yards per game last season, which ranked fifth in the NFL.
Linebacker Fred Warner headlines a defense that gave up just 16.3 points per game in 2022, the fewest in the league. The Steelers, meanwhile, scored 18.1 points per game on average a season ago, and SportsLine's model expects they'll finish below that number in Week 1. According to the model, the 49ers hold the Steelers to just 17 points, helping San Francisco cover the spread well over 50% of the time. See which other NFL parlay picks to make here.
How to make Week 1 NFL parlays
The model also jumped on four other NFL matchups where it says the line is way off, including a pair of underdogs that have a chance to win outright. You can only see the model's NFL Week 1 best bets and parlay at SportsLine.
What are the model's top Week 1 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 163-113 run on its top-rated picks, and find out.
