49ers vs. Falcons Picks, Predictions NFL Week 6: Garoppolo & Co. to Stay Hot in Atlanta

Kyle Shanahan returns to Atlanta as the Falcons' offensive coordinator. San Francisco has two wins in a row and is the best defense in the league. The Falcons are missing key personnel on offense.

The 49ers are 6.5-point favorites against the Falcons. Around 70% of the handle is on the 49er's ticket.

49ers vs. Falcons is a big spread. Jimmy Garoppolo is expected to pass for over 1.5 passing touchdowns.

49ers vs. Falcons is a game to watch in NFL Week 6. The spread is Falcons +5.5 (-107 via PointsBet) and the over/under is 44.

The Falcons are 5-0 against the spread this year. The 49ers are banged up and without several key players. Atlanta made a strong push late in its game last week against a Tampa Bay Buccaneers defense.

49ers defense has allowed the fewest points, fewer rushing yards and fewesteak receiving yards in the league. Cordarrelle Patterson is still on IR for the Falcons, while Pitts returned to practice this week.

Jimmy Garoppolo has improved his numbers in each game this season. Tevin Coleman has the highest TD-per-reception ratio in the NFL. The 49ers have based themselves in West Virginia all week.

49ers vs. Falcons is in Week 6 of the NFL. The picks are made on 10/13/2022 at 7:01 a.m. ET.