Chargers vs. San Francisco 49ers: Betting odds, lines and picks
The San Francisco 49ers are favored to beat the Los Angeles Chargers on Sunday Night Football. The Chargers beat Atlanta Falcons 20-17 coming out of the bye.
The Chargers beat the Falcons last week. The 49ers are coming off of a bye week and are playing without two key players. Christian McCaffrey had 149 rushing + receiving yards in the win over the Rams. Keenan Allen and Mike Williams are injured. Justin Herbert threw 43 times against the Atlanta Falcons. The team's longest touchdown play this season is 23 yards. San Francisco is a top-10 or top five defense. It seems unlikely that the Chargers defense will hold up. Jimmy Garoppolo and the passing attack have been surprisingly good. Chargers are short on playmakers on offense.
