Bills vs. Dolphins prediction, odds, line, spread: 2022 NFL picks, Week 15 best bets by model on 157-113 run

Bills vs. Dolphins is a final regular season game for both teams. Miami won the first game in Orchard Park in Week 3. Buffalo is 10-3 overall and 5-1 at home. Caesars Sportsbook lists the Bills as seven-point home favorites. The over/under is 43.5 in the latest Dolphins vs., latest Vegas odds. SportsLine's advanced computer simulation model simulates every NFL game 10,000 times and is up more than $7,100 for $100 players on top-rated NFL picks since its inception.

SportsLine's computer model has set its sights on Dolphins vs. Bills and has made its picks and NFL predictions. Dolphins are 6-7 against the spread this season. Buffalo is 6.6-1 against this year's spread.

Bills vs. Dolphins is a game with a 7-point spread. The Dolphins are 6-7 against the spread this season. Bills are currently 6.6-1 against spreads this year.

The Dolphins are averaging 24.3 points per game and 367.8 yards per contest. Miami is No. 2 in the league in passing yards with 3,613. The Dolphins have a pair of 1,000-yard wide receivers already this season. Dolphins quarterback Tua Tagovailoa is the best in his position.

Josh Allen and Stefon Diggs form one of the best quarterback-receiver duos in the NFL. Buffalo is in top four in points per game, points, drives, and total yards. The team is also in No. 2 in scoring defense and giving up only 17.0 points a game.

SportsLine's model is leaning Over on the point total. Both teams are projected to throw for more than 250 yards. One side of the spread hits in well over 50% of simulations.