Bills vs. Dolphins prediction, odds, line, spread: 2022 NFL picks, Week 15 best bets from model on 157-113 run

Buffalo Bills host Miami Dolphins at 8:15 p.m. ET on Saturday. The Bills are 10-3 overall and 5-1 at home this season. Miami is 8-5 overall, 3-4 on the road and 6-7 against the spread. SportsLine's advanced computer simulation model simulates every NFL game 10,000 times and has returned a profit of more than $7,100 for $100 players on top-rated NFL picks since its inception.

SportsLine's computer model has set its sights on Dolphins vs. Bills and has made its picks and NFL predictions. Dolphins are 6-7 against the spread this season. Buffalo is 6.6-1 against-the-spread this year.

Dolphins vs. Bills is a game with a spread of 7 points. Dolphins are 6-7 against the spread this season. Buffalo is 6.6-1 against spreads this year.

The Dolphins are averaging 24.3 points per game and 367.8 yards per contest. Miami is No. 2 in the league in passing yards with 3,613. The Dolphins have a pair of 1,000-yard wide receivers already this season. Dolphins quarterback Tua Tagovailoa is the best in his position.

Buffalo is the second-best defense in the NFL and the No. 4 offense. Josh Allen is a prolific passer and rusher. The model has a 157-113 record on its best bets from the Dolphins.

SportsLine's model is leaning Over on the point total. Both teams are projected to throw for more than 250 yards. One side of the spread hits in well over 50% of simulations.