Cardinals vs. Rams Picks, Predictions Week 10: Will Cooper Kupp Feast Against Leaky Defense?

The Los Angeles Rams have the home advantage against the Arizona Cardinals. Los Angles is 10-1 against Arizona since 2017. The only team with more wins against a single opponent since 2018 is the Patriots, who are 11-0 against Jets.

The Rams opened as 3-point favorites, but the public has driven that down with 54% of the cash placed on the home team. The total has also dropped from 45 to 40.5.

Cardinals vs. Rams is a game with a spread of 1.5 points. The over/under is 40.

Cardinals vs. Rams is a big game. The Rams are favored by 1.5 points.

The Rams beat the Cardinals 20-12 in Week 3. Arizona lost to the Seahawks 31-21 at home last week. The Rams lost 16-13 to Tampa Bay last time. Rams are 5-5 in divisional games on the road.

Kyler Murray has thrown multiple touchdown passes in each of his last two games. DeAndre Hopkins has averaged 99 receiving yards per game in his three starts since returning to the Cardinals’ starting lineup following an eight-game suspension. James Conner made a positive return from injury last week. Cardinals will pose a threat on offense, but their defense has been poor this season.

Last week was Cooper Kupp's 20th career game with at least 100 receiving yards and a touchdown. On Sunday, Kpp and the Rams face an Arizona defense that has given up the third-most points, third most passing yards, and most red zone touchdowns this season.

Cardinals vs. Rams picks made 11/11/2022 at 5 p.m. ET.