Cardinals vs. Rams prediction, odds, line, spread, time: 2023 NFL picks, Week 12 best bets from computer model
The Arizona Cardinals have played two competitive games since the return of quarterback Kyler Murray from an ACL injury and look to win their second game in three weeks as they host the Los Angeles Rams on Sunday afternoon. Arizona (2-9) fell at Houston, 21-16, while Los Angeles (4-6) edged Seattle, 17-16 in Week 11. The Rams won this NFC West division matchup earlier this season, 26-9 in Week 6. Arizona is 5-5-1 against the spread, while Los Angeles is 4-5-1 ATS in 2023.
Kickoff from State Farm Stadium in Glendale is set for 4:05 p.m. ET. Los Angeles is a 2.5-point favorite in the Cardinals vs. Rams odds via SportsLine consensus, while the over/under is 45. Before making any Rams vs. Cardinals picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2023 NFL season on an incredible 175-126 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 29-18 roll on top-rated NFL picks since Week 7 of last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!
Now, the model has set its sights on Rams vs. Cardinals and just locked in its picks and NFL Week 12 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Cardinals vs. Rams:
- Cardinals vs. Rams spread: Rams -2.5
- Cardinals vs. Rams over/under: 45 points
- Cardinals vs. Rams money line: Rams -135, Cardinals +114
- Cardinals vs. Rams picks: See picks at SportsLine
- Cardinals vs. Rams live stream: fubo (try for free)
Why the Rams can cover
Los Angeles swept the season series with Seattle after trailing 16-7 heading into the fourth quarter last week. In his return from a one game absence, quarterback Matthew Stafford completed 17 of 31 passes for 190 yards with one touchdown and one interception. He was without his top wide receiver, Cooper Kupp, who sprained an ankle earlier in the game. Kupp is expected to play this week.
In Kupp's absence, rookie WR Puka Nacua caught five passes for 70 yards and a score. The Rams' fifth round pick now has 69 catches for 897 yards and three touchdowns this season. Los Angeles should also be bolstered by the return of running back Kyren Williams (ankle) from injured reserve. Williams rushed 20 times for 158 yards and a touchdown in this matchup earlier this season. See which team to pick here.
Why the Cardinals can cover
Arizona's franchise quarterback returned from a lengthy absence in Week 10 and has showed no ill affects of the torn ACL that sidelined him since late last season. In two games, Murray has thrown for 463 yards with one touchdown and two interceptions, while rushing for 84 yards on 13 attempts with two scores. His dynamic scrambling ability will be key against a solid Los Angeles pass rush led by future Hall of Fame defensive tackle, Aaron Donald.
Second year tight end Trey McBride has been a favorite target of Murray's thus far, catching 13 passes for 174 yards combined in the two games they've played together this season. For Arizona to maximize its success through the air on Sunday, Murray will have to better utilize his college teammate, wide receiver Marquise Brown. With only three catches for 46 yards the last two weeks, Brown hasn't been able to show the game breaking ability Arizona expects having acquired him for a first round draft pick from Baltimore in 2022. See which team to pick here.
How to make Rams vs. Cardinals picks
The model has simulated Los Angeles vs. Arizona 10,000 times and the results are in. It is leaning Under on the point total, and it also says one side of the spread hits more than 50% of the time. You can only see the model's Cardinals vs. Rams pick at SportsLine.
