Rams vs. Cardinals prediction, odds, spread, start time: 2023 NFL picks, Week 6 best bets from proven model
The Arizona Cardinals look to win their third consecutive regular season game in southern California as they face the Los Angeles Rams on Sunday afternoon. Arizona (1-4) fell last Sunday to Cincinnati, 34-20, while the Rams (2-3) lost at home to Philadelphia, 23-14. The road team has won each of the last four regular season meetings, though the Rams defeated Arizona at home in the 2021-22 Wild Card Round. Arizona is 3-2 against the spread, while Los Angeles is 3-1-1 ATS in 2023.
Kickoff at SoFi Stadium in Inglewood, Calif., is scheduled for 4:25 p.m. ET. Los Angeles is favored by 7 points in the latest Cardinals vs. Rams odds, and the over/under for total points scored is 47.5. Before making any Rams vs. Cardinals picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2023 NFL season on an incredible 171-119 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 25-11 roll on top-rated NFL picks since Week 7 of last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Cardinals vs. Rams and just locked in its picks and NFL Week 6 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Rams vs. Cardinals:
- Rams vs. Cardinals spread: Rams -7
- Rams vs. Cardinals over/under: 47.5 points
- Rams vs. Cardinals money line: Rams -324, Cardinals +254
- Rams vs. Cardinals picks: See picks at SportsLine
- Rams vs. Cardinals live stream: fubo (try for free)
Why the Cardinals can cover
Arizona's active roster is already among the league's worst on paper and it's even more depleted this week with the loss of running back James Conner for at least four weeks due to a knee injury. Conner had been averaging 5.4 yards per carry this season and his loss will fall on replacements Keaontay Ingram and undrafted rookie Emari Demercado. After Conner was hurt last week, Demercado rushed 10 times for 45 yards and a score in the team's defeat, while Ingram was inactive due to injury.
Quarterback Joshua Dobbs had been efficient this season before last week's effort against the Bengals, where he completed 15 of 32 passes for only 166 yards, with two touchdowns and his first two interceptions of 2023. Arizona's top wide receiver, Marquise Brown, has been targeted 42 times on the season, with 25 catches for 300 yards and three touchdowns to his credit. Against a Rams secondary which surrendered two 100-plus yard receivers last week, Brown might be able to find success and keep Arizona in the game. See which team to pick here.
Why the Rams can cover
If Arizona's pass defense is comparable to last week's effort, the Rams should have a field day on Sunday. Matthew Stafford is fourth in the league in passing yards and already boasts three 300+ yard passing games this season. While he's only thrown five touchdown passes, those have somewhat been offset by the five interceptions he has thrown. The good news for him is that Arizona gives up 251.4 yards per game through the air, the seventh worst in the league.
Last Sunday, Cincinnati's Ja'Marr Chase caught 15 passes for 192 yards and three scores against the Cardinals, even without the presence of a true No. 2 wide receiver. It seems apparent that Arizona should have no answer for Cooper Kupp and rookie sensation Puka Nacua, who combined for 15 catches for 189 yards and a touchdown against Philadelphia last week. Los Angeles' game plan is likely to include passing early and often against the Cardinals' undermanned secondary. See which team to pick here.
How to make Cardinals vs. Rams picks
The model has simulated Rams vs. Cardinals 10,000 times and the results are in. It is leaning Under on the point total, and it also says one side of the spread has all of the value. You can only see the model's Rams vs. Cardinals pick at SportsLine.
