Rams vs. Cardinals prediction, odds, line, spread: 2022 NFL picks, Week 3 best bets from proven computer model

Matthew Stafford and the Los Angeles Rams take on Kyler Murray and Arizona Cardinals at 4:25 p.m. ET on Sunday at State Farm Stadium in Glendale. Both teams have 1-1 records and both won their last two games. Los Angles is favored by 3.5 points in the latest Cardinals vs. Rams odds from Caesars Sportsbook. The over/under is set at 48.

The SportsLine computer model has selected its picks and NFL predictions for Cardinals vs. Rams. The model is using the Rams -3.5 as the spread.

Rams are 3.5 points ahead of Cardinals. The over/under for the game is 48.

Arizona Cardinals beat the Las Vegas Raiders 29-23 in overtime. The Cardinals were down 20-0 at the half. Arizona got scores from Greg Dortch and Darrel Williams. They also got a gritty performance from quarterback Patrick Murray.

The Rams beat the Atlanta Falcons 31-27 this past Sunday. Los Angeles hasn't played up to the standards set by their Super Bowl win last season. The Rams have a lot of new players and they need time to gel.

The model simulates Cardinals vs. Rams 10,000 times and has generated a point-spread pick that is hitting in well over 50% of simulations.