Rams vs. Cardinals odds, line, spread: 2022 NFL picks, Week 10 predictions from proven computer model

The Los Angeles Rams and Arizona Cardinals are playing each other on Sunday at 4:25 p.m. ET. Los Los is 3-5 on the season and has lost four of its last five games. Arizona is struggling at 3.6 and is favored by 3 points. The over/under is set at 38.5. SportsLine's computer model simulates every NFL game 10,000 times and it has returned an incredible 151-108 results on top-rated NFL picks since it was launched in 2017.

Rams vs. Cardinals is a Week 10 NFL game. Rams are the favorite by 3 points. The over/under is 38.5 points and the money line is Los Angeles -155 and Arizona -130.

Rams vs. Cardinals is a NFL game. Rams are favored by 3 points. The over/under is 38.5 points and the money line is Los Angeles -155 and Arizona -130.

The Rams have won 11 of the last 12 games against Arizona. Arizona has lost all three divisional games this season. Rams are reigning Super Bowl winners and have a talented roster. Cooper Kupp is fourth in the NFL with 813 receiving yards.

Rams have been terrible this season and are 31st in the league in total yards. John Wolford is in his fourth season with the Rams but has thrown just 42 career passes. Arizona linebacker Zaven Collins recorded a pick-six against Seattle last week.

The model has simulated Cardinals vs. Rams 10,000 times and the results are in. SportsLine's model is leaning Over.