49ers vs. Chargers odds, spread, line: Sunday Night Football picks, predictions from NFL model on 151-108 run

49ers vs. Chargers is a Sunday Night Football game. San Francisco is 7.5 points favorite. The over-under for points scored is 45. Los Angeles is coming off a 20-17 victory at Atlanta. SportsLine's advanced computer model simulates every NFL game 10,000 times and is up more than $7,100 for $100 players on top-rated NFL picks since its inception.

The model has set its sights on 49ers vs. Chargers and has made its NFL picks and predictions. San Francisco is 6-1 against the spread in their last seven home games. Los Angeles is 4-0 ATS on the road this season.

49ers vs. Chargers is Sunday Night Football. The 49ers are 6-1 against the spread in their last 7 home games. Los Angeles is 4-0 ATS on the road this season.

Christian McCaffrey made his debut for the 49ers. He gained 38 yards on eight carries and two catches for 24 yards. McCafrey became the first player since LaDainian Tomlinson in 2005 to record a passing, rushing and receiving touchdown in the same game. Jimmy Garoppolo had two touchdown passes in his fourth straight game, the longest such streak since Alex Smith's run in 2009.

The Chargers possess a dangerous aerial attack. Austin Ekeler has recorded both a rushing and receiving touchdown four times over his last five games. Justin Herbert is fifth in the league in passing yards. He is tied with Andrew Luck for the most 300-yard performances through their first five seasons since 1950.

SportsLine's model is leaning Over on the total and predicts the teams will combine for 50 points. One side of the spread cashes in well over 50% of simulations.