Cubs vs. Reds odds, prediction, line: 2022 MLB picks, Monday, May 23 best bets from proven model

The Chicago Cubs and Cincinnati Reds meet on Monday at 6:40 p.m. ET. Chicago is a -130 favorite on the money line. The over-under for total runs scored is nine. SportsLine Projection Model simulates every MLB game 10,000 times. It's on a 41-30 roll on top-rated MLB money-line picks through seven weeks.

SportsLine's computer model has made its picks and MLB predictions for Cubs vs. Reds. Chicago is 2-7 in their last 9 series openers and 1-9 in last 10 against left-handed starters.

Cubs are 2-7 in their last 9 series openers. Reds are 1-9 in last 10 games against left-handed starters.

Patrick Wisdom and Frank Schwindel hit back-to-back home runs in the eighth inning to help Chicago beat Cincinnati. Wisdom has hit home run in three consecutive games and leads Chicago with nine. P.J. Higgins made his season debut on Sunday and recorded three RBI. Drew Smyly is 3-0 with a 3.09 ERA and 26 strikeouts over 23.1 innings in five career games against Cincinnati and is a potential ace for the team.

Cincinnati has won nine of 15 games since a nine-game losing streak from April 26-May 5. Kyle Farmer has been one of the hottest hitters at the plate during his five-match hitting streak. Brandon Drury will be back for the weekend series at Toronto after being placed on the restricted list due to his being unvaccinated.

Cubs vs. Reds is on Monday, May 23.