Giants vs. Panthers odds, line, spread, prediction: 2022 NFL picks, Week 2 best bets by model on 139-98 run

The New York Giants host the Carolina Panthers in their 2022 home opener at MetLife Stadium on Sunday at 1 p.m. ET. New Jersey is a 2-point favorite in the latest Panthers vs. Giants odds from Caesars Sportsbook. The over/under is 43.5. SportsLine's computer model simulates every NFL game 10,000 times and has returned a 139-98 record on top-rated NFL picks since it was launched in 2017.

SportsLine's computer simulation simulated Giants vs. Panthers 10,000 times and revealed its NFL expert picks and predictions. Giants are 17-8-1 ATS versus teams with losing records.

Giants vs. Panthers is a game with a 43.5-point over/under. The money line is New York -130. Carolina is 4-1 ATS in their last five games in September. Giants are 17-8-2 AATS versus teams with losing records.

Daniel Jones is a good quarterback and a smart route runner. Sterling Shepard is an elusive receiver with reliable hands. Richie James is shifty in the slot. The Giants won last week. The game is at New York.

Carolina's offense has plenty of playmakers, including Christian McCaffrey, D.J. Moore and Robbie Anderson. The Temple product Moore led the team last week with five receptions for 102 yards, and a 75-yard touchdown grab.

SportsLine's computer model has a 139-98 record on its best bets from Week 2. It's leaning Under the total and has strong against the spread pick.