Michigan vs. Iowa prediction, odds, spread: 2022 Week 5 college football picks, best bets from proven model

No. 4 Michigan Wolverines visit Iowa Hawkeyes in a conference battle at Kinnick Stadium on Saturday afternoon. This is the first time the teams have met in Iowa City since 2016. Michigan is 4-0 overall and 1-1 in the Big Ten this season. Iowa is 3-2 overall, 1 of 2 in conference play. SportsLine's proven computer model simulates every FBS college football game 10,000 times and has returned a profit of more than $3,100 for $100 players on its top-rated college basketball picks against the spread.

Michigan and Iowa are playing each other in the Week 5 college football game. The Wolverines are 2-2 against the spread in their last four games. Iowa is 2.1-1 against a spread against Michigan in its last three games, including 2 against against them in last 3 games against this team.

Michigan is 2-2 against the spread in the last four games. Iowa is 3-1 against a spread against Michigan in last three games, including 2.1 points per game.

Michigan is ranked No. 2 in the FBS this season and is tied for the lead with 17 rushing touchdowns. Michigan is generating 234.3 rushing yards per game and 6.0 yards. The Wolverines are also converting 46. 3% of third-down chances. Iowa is scoring 17.5 points per games and producing 232. 5 yards, but it's a bad team.

Iowa's defense is excelling in the 2022 season. The Hawkeyes are leading FBS in scoring defense and giving up only 5.8 points per game. Iowa is also giving only 236.3 yards per match and 4.6 yards on passes. No opponent has scored more than 10 points against Iowa this season, and Iowa has won the last four games against Michigan at Kinnick Stadium.

SportsLine's model is leaning Over the total and projecting 49 combined points for Michigan vs. Iowa. It has also generated an against the spread pick that hits in almost 60% of simulations.