Iowa State vs. Ohio odds, line: 2022 college football picks, Week 3 predictions from proven computer model

Iowa State Cyclones are favored by 18 points against the Ohio Bobcats. The Cyclone's last week's win over Iowa was a 3.5-point underdog. Ohio was beaten 46-10 by Penn State last Saturday. Kickoff is set for 2 p.m. ET. SportsLine's computer model simulates every FBS college football game 10,000 times and has returned a profit of almost $3,400 for $100 players on its top-rated collegefootball picks.

Iowa State is a college football team. Ohio is an FBS team that plays in the Big Ten. Iowa State and Ohio are going to play each other in Week 3.

Iowa State is a -18 favorite against Ohio. The game is expected to be won by Iowa State.

Iowa State has already dominated one bad team this season, blowing out Southeast Missouri State in a 42-10 final in its opener. The Cyclones followed that performance with a 10-7 win at Iowa last week. Iowa State is on a five-game home winning streak. Ohio is just 4- 10 in the last 14 games overall.

Iowa State is coming off a big win over its rival and has a game against No. 17 Baylor next week. Ohio won its first game of the season against Florida Atlantic and played at Penn State last week, so it's not going to be intimidated by Iowa State. Iowa covered the 33.5-point spread against Southeast Missouri State in their season opener.

The model simulates Ohio vs. Iowa State 10,000 times and it has generated a point-spread pick that is hitting in well over 50% of simulations.