College Football Odds: Louisville vs Clemson prediction, odds, pick

Clemson lost to Notre Dame 35-14 last week. The Tigers are now in danger of missing out on the College Football Playoff. They have to win out against Louisville. Louisville lost in the first game to Syracuse, but has since won several games. The team is also in good form after a loss at Boston College. It's a good time to pick Louisville to beat Clemson. For more information on our college football odds series visit the website here. for our Louisville Clemson prediction and pick. and for more odds about collegefootball.com visit our website. to find out more.

Louisville has been playing good defense and should be able to keep this game close with its defense. Clemson is not going to run away and hide.

Louisville is the favorite against Clemson.

Clemson is coming off a bad performance against Notre Dame. Louisville is a better team than Clemson.

Louisville is favored by one touchdown against Clemson.

Louisville and Clemson are playing each other.