Michigan vs. Indiana Picks, Predictions College Football Week 6: Wolverines Expected to Thrive

Michigan has won all but one game this season by a double-digit margin. The exception was a 34-27 win over Maryland two weeks ago. Michigan won 27-14 over Iowa last week. Indiana has suffered back-to-back losses coming into Week 6.

Michigan plays Indiana at Memorial Stadium, Bloomington, Indiana on Saturday, October 8 at noon ET. The weather is 57 degrees, 0% chance of precipitation, 3-mph winds.

Michigan vs. Indiana is a game with a consensus opening line of Michigan -22.5. 70% of the tickets and 77% are backing the Wolverines. The Over/Under was bumped up from 58 to 58.

Michigan is 9th in offensive efficiency and is expected to score 27 points against Indiana's top 10 defense. Indiana is undefeated at home this season, but lost to Nebraska by multiple touchdowns last weekend. Michigan hasn't won against the spread this year.

Michigan averages 45.4 points per game and has scored below 34 points only once in 2022. Indiana's offensive efficiency is 81st, but the team hasn't fallen below 20 points in any of its games this season. Michigan's defense is No. 13 in the country. The game should finish in a close score of 45-17.

The Wolverines have been a dynamite team in opening games this season. Indiana is 3-2 on the campaign but hasn't led after the first quarter in any of their five games. The Hoosiers host a capable team on Saturday.

Michigan-Indiana picks are made 10/5/2022 at 4:26 p.m. ET.