Michigan vs. UConn odds, prediction, line: 2022 Week 3 college football picks from model on 50-41 run

Jim Harbaugh's Michigan Wolverines take on Jim Mora Jr.'s UConn Huskies on Saturday at noon ET. The Wolverine's are 2-0 this season and the Husky's 1-2. Caesars Sportsbook lists Michigan as 47.5-point home favorites. SportsLine's advanced computer simulation model simulates every FBS college football game 10,000 times. It has generated a profit of almost $3,400 for $100 players on its top-rated college college game picks against the spread.

The model has set its sights on UConn vs. Michigan and has made its picks and CFB predictions. The model is using the following odds and betting lines: Michigan -47.5, Uconn -8, and over/under 58.

Michigan is 12-4 against the spread in the last 16 games. UConn is 8-7 against spread against Michigan in last 15 games and is favored by 47.5 points.

UConn has statistical strengths on both sides of the ball to this point in the season. The Huskies are averaging more than 200 rushing yards per game and 5.1 yards a carry this season, while their defense is also very good. Michigan has struggled on third down and converted only 31% of chances.

Michigan is on a 16-game winning streak against unranked non-conference opponents. Michigan is one of only three FBS teams to score at least 50 points in each game this season. The Wolverines are averaging 251 rushing yards per game and 514 total yards. JJ McCarthy takes over as the team's starting quarterback this week.

SportsLine's model is leaning Over on the total. The model also says one side of the spread hits more than 50% of time.