Monday Night Football odds, line: Chargers vs. Colts prediction, NFL picks, best bets by expert on 22-9 run

The Los Angeles Chargers are playing on Monday Night Football against the Indianapolis Colts. Los Angles has won seven of 11 games and is in the 2022 NFL playoffs. The Colts have lost four consecutive games, seven out of eight and are 4-9-1. Nick Foles will start for the Colts at quarterback. LA is a 3.5-point favorite.

SportsLine's Mike White has made his picks and NFL predictions for Monday Night Football. Los Angeles Chargers are 5-2 against the spread in their last 7 games following an ATS loss. Indianapolis Colts are unbeaten in last 5 games after allowing more than 30 points in the previous game.

The Chargers are 5-2 against the spread in their last 7 games following an ATS loss. The Colts are now 5 -0 AET in last 5 games after allowing more than 30 points in the previous game.

Gerald Everett is a key player for the Chargers. Khalil Mack is making an impact on the defensive side. The Colts are the team to beat on Monday Night Football.  

Michael Pittman Jr. is the team's leading receiver with 86 receptions for 815 yards and two touchdowns. Parris Campbell is second-leading receiver, with 52 receptions, 510 yards (9.8 average) and three touchdowns, and his best game was a 10-catch, 70-yard and one-touchdown performance in a 19-10 loss at Tennessee on Oct. 23.

White is leaning Under the point total for the Colts vs. Chargers. He has discovered a critical X-factor that has him jumping all over one side of the spread.