Thursday Night Football odds, spread, line: Colts vs. Broncos predictions, NFL picks by expert who is 36-24

Matt Ryan and the Indianapolis Colts will take on Russell Wilson and Denver Broncos on Thursday Night Football at 8:15 p.m. ET. Both teams have two losses in 2022. Jonathan Taylor and Javonte Williams are injured. The Broncos are 3-point home favorites. SportsLine's resident Colts expert, R.J. White, is a top NFL expert. He's gone 445-378-24 on his ATS picks from 2017-21 and 36-25-2 on NFL picks involving the Colts.

Colts vs. Broncos is Thursday Night Football. Colts are 11-10 against the spread in their last 21 games. Denver is 9-12 against-the-spread in its last21 games, including 9/12 in the last two weeks.

Colts vs. Broncos is a game with a 3-3 spread and 42 points. Colts are 11-10 against the spread in their last 21 games. Denver is 9-12 against-the-spread in its last21 games and are 9th in the last 20.

Colts are in the top 10 with 252 passing yards per game and land above the league average in first downs and third-down conversion rate. Matt Ryan is No. 4 in NFL with 1,125 passingyards this season and No 7 with 102 completions. Wide receiver Michael Pittman has caught 82 passes for 1.082 yards and six touchdowns this year. Denver has a stout defense, but the Broncos yielded 32 points and 212 rushing yards in a Week 4 loss to the Colts.

The Broncos have only four turnovers this season and are turning the ball over on only 9.1% of possessions. No team has fewer interceptions than the Broncos. The team's quarterback is Russell Wilson, who has a 7.5 yards per attempt and is flanked by an experienced running back in Melvin Gordon. Courtland Sutton and Jerry Jeudy are the team with the best wide receivers in the league.

Colts vs. Broncos is a Thursday Night Football game. SportsLine's Mike White is backing the Under.