Notre Dame vs. USC Picks, Predictions College Football Week 13: Can Trojans Keep CFP Hopes Alive?

The 93rd game of the Notre Dame-USC rivalry takes place on Saturday. NotreDame improved to 8-3 and is in the midst of its longest winning streak (five games). The Fighting Irish have beaten three ranked teams and control which teams will make the College Football Playoff. USC (10-1, 8 -1) would be eliminated with a second loss.

Notre Dame vs. USC is on Saturday, November 26 at 7:30 p.m. ET. It's in Los Angeles Memorial Coliseum. The weather is 72 degrees, 1% chance of rain, 4-mph SSE wind.

USC was installed as a six-point favorite, but the spread now sits at -4. Notre Dame is drawing 63% of the cash and 51% from tickets. The total has also undergone two-way action, where it opened at 63.5 points but now is 64.

Notre Dame vs. USC is a college football game. The spread is 5.5 (-110 via BetMGM), the over/under is 64. 5 (-105 via FanDuel), and the prop bet is Caleb Williams over 2.0 passing touchdowns (-130 via DraftKings).

Notre Dame vs. USC is a college football game. The spread is 5.5 points. Over/Under is 64.

Notre Dame is a heavy favorite against USC. The Fighting Irish are coming off a 44-0 win over Boston College. USC has the fourth-ranked passing attack. They are expected to pose problems for the Fighting Indian defense. USC is expected by many to cover for 10th time in the last 13 games as the favorite.

Notre Dame and USC have each had the Over cash in each of their last five games. The Fighting Irish average 31.0 points per game behind a dominant rushing attack. USC has the better time of possession (38:13 to 21:47). FanDuel is most appealing for Over backers.

Notre Dame plays USC in the CFP game. The team's CUP hopes are on the line. USC's quarterback, Williams, has 33 passing touchdowns in 11 games.

Notre Dame vs. USC is a college football game on 11/25/2022 at 7:19 a.m. ET.