Notre Dame Fighting Irish vs. USC Trojans Prediction, Odds, Lines, Spreads, and Picks- November 26

Notre Dame Fighting Irish are on a five-game winning streak. They come into the Coliseum to take on the USC Trojans. The Notre Dame/USC rivalry has been the subject of many college football history books.

Notre Dame Fighting Irish vs. USC Trojans is a football game on November 26th.

Notre Dame Fighting Irish vs. USC Trojans is on Saturday, November 26 at 7:30 PM ET at Los Angeles Memorial Coliseum.

Caleb Williams is making a compelling case of being the best college football quarterback. USC Trojans withstood a challenge from the UCLA Bruins and were able to walk away victorious. Notre Dame Fighting Irish have been playing exceptionally well lately and bring a defensive prowess that USC have not seen in 2022.

Notre Dame Fighting Irish and USC Trojans are playing for the national championship. USC will win the game. Notre Dame might slow down the Trojan's offense, but they don't have enough firepower to keep up with Caleb Williams and the Trojan's for four quarters.