Notre Dame vs. USC predictions: College football picks, odds today

No. 15 Notre Dame and No. 6 USC are playing in the regular-season finale on Saturday at 7:30 p.m. ET. The Trojans are hoping to make it into the College Football Playoff.

Notre Dame and USC are both having successful seasons under new coaches. The Fighting Irish have won eight of nine games in the last nine years.

Notre Dame is on a five-game winning streak. The last two games against ranked opponents were also blowouts. USC's defense is ranked 65th nationally and allows 26.3 points per game. Notre Dame has only beaten USC three times in the last 11 games.

Notre Dame and USC have not played a lot of low-scoring games in recent weeks. Notre Dame's last five games averaged 57.6 points and the last 5 games of USC's average 81.5 points. Caleb Williams has one final chance to make a Heisman statement.

Caleb Williams has scored four rushing touchdowns in his last three games. All of them have come in the first half. Six of his seven rushing touchdown have been at home. Caesars Sportsbook has Caleb Williams over 0.5 rushing TDs @ +120 with Caeres Sports.