Ohio State vs. Northwestern prediction, odds: 2022 Week 10 college football picks, best bets by proven model

Ohio State Buckeyes are 38-point favorites against Northwestern Wildcats. Kickoff is set for noon ET from Northwestern's Ryan Field. Ohio State won the first-ever CFP title in 2015 and has returned twice since. Northwestern is 1-7 and on a seven-game losing streak. SportsLine's advanced computer model simulates every FBS college football game 10,000 times. It has generated a stunning profit of almost $3,300 for $100 players on its top-rated college Football picks against the spread.

Ohio State is a 38-point favorite against Northwestern. The Wildcats have covered the spread in three of their past five conference games as a double-digit underdog. Ohio State's road team is 5-1 against the odds in the last six meetings in this rivalry.

Ohio State is a more than five-touchdown favorite against Northwestern. Ryan Day's team was voted in the No. 2 spot in College Football Playoff rankings. The teams met in Big Ten title game two years ago. Northwestern took a 10-6 lead at half but Ohio State responded with 16 unanswered points.

Brendan Sullivan took over at quarterback for Northwestern two weeks ago and has helped generate the team's highest point total since its season-opening victory against Nebraska. Ryan Hilinski is more of a classic pocket passer and struggled under a heavy pass rush against Iowa.

SportsLine's model is leaning Over on the total. It projects a combined 58 points for Northwestern and Ohio State. One side of the spread hits in well over 60% of simulations.