Northwestern vs. Duke odds, line: 2022 college football picks, Week 2 predictions from proven computer model

Northwestern Wildcats are favored by 9.5 points against Duke Blue Devils. Northwestern beat Nebraska 31-28 in the season-opening game. Duke is coming off a 30-0 victory over Temple. Kickoff is set for noon ET. SportsLine's computer model simulates every FBS college football game 10,000 times. It has generated a profit of almost $3,500 for $100 players on its top-rated college Football picks against the spread.

Northwestern vs. Duke is a college football game on Saturday. Northwestern is favored by 9.5 points. The game is expected to be won by 54 points or more.

Northwestern vs. Duke is a college football game. Northwestern is favored by 9.5 points.

Northwestern won its season opener against Nebraska. Northwestern has a rest advantage over Duke after getting a week off in between games. Duke has failed to cover the spread in eight consecutive road games and has not played well against high-level competition.

Duke was a 9.5-point favorite against Temple, but they won 30-0. It was the Blue Devils' first shutout win against an FBS team since 1989 at North Carolina. Head coach Mike Elko picked up a win in his debut with the team. Northwestern has only covered the spread twice in its last seven games.

Northwestern is playing Duke in the 2022 college football season. SportsLine's computer model simulates Northwestern vs. Duke 10,000 times and has generated a point-spread pick that is hitting in well over 50% of simulations.