Ohio vs. San Diego State line, picks: Advanced computer college football model releases prediction, best bets for season opening matchup

College Football Week 0 kicks off with the Ohio Bobcats battling the San Diego State Aztecs on Saturday at 7 p.m. ET from Snapdragon Stadium in San Diego. The Aztecs are 2-point favorites, while the over/under is set at 49 (see up-to-date odds for every game this week on our college football odds page) in the latest Ohio vs. San Diego State odds. 

Before making any Ohio vs. San Diego State picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows senior quarterback Jalen Mayden is back for the Aztecs. The second-year starter completed 141 of 237 passes (59.5%) for 2,030 yards and 12 touchdowns with 10 interceptions in 2022. He also rushed 69 times for 231 yards (3.3 average) and three touchdowns. Mayden was named an honorable mention all-Mountain West selection at quarterback, despite playing only the final seven games.

The model also knows the Bobcats return graduate quarterback Kurtis Rourke. Rourke completed nearly 70% of his passes last season, hitting on 244 of 353 passes for 3,256 yards and 25 touchdowns. He was only picked off four times. He also was the Bobcats' third-leading rusher, carrying 74 times for 249 yards (3.4 average) and four touchdowns.

Now, it has set its sights on Ohio vs. San Diego State. We can tell you the model is leaning Over on the point total, and it also says one side of the spread hits in more than 70% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.