Penn State vs. Central Michigan odds, line: 2022 college football picks, Week 4 predictions from proven model

The Central Michigan Chippewas are on the road to play the No. 14 Penn State Nittany Lions on Saturday at noon ET. The Nissany lions are favored by 28 points. SportsLine's computer model simulates every FBS college football game 10,000 times and has returned a profit of more than $3,300 for $100 players on its top-rated college Football picks against the spread.

Penn State vs. Central Michigan is a college football game. The game is scheduled for Saturday. Penn State is favored by 28 points.

Penn State vs. Central Michigan is a college football game. The line is Penn State -28.5.

Penn State won its first game of the season against Purdue. The Nittany Lions beat Auburn 41-12 last week. Central Michigan is a 3.5-point road favorite. Penn State has won and covered in 14 of its last 20 games.

Central Michigan beat Bucknell 41-0 last week. Penn State is playing a conference game against Northwestern next week before this game. Central Michigan has covered the spread in eight of its last 11 road games.

The model simulates Central Michigan vs. Penn State 10,000 times and it has generated a point-spread pick that is hitting in almost 60% of simulations.