Clemson vs. Notre Dame Picks, Predictions College Football Week 10: Can Tigers extend Winning Streak?

Clemson and Notre Dame are playing each other in the college football Week 10. Clemson has won 14 straight games. Notre Notre won the last time they played in South Bend 47-40 in double overtime. The Tigers have won six points in each of their last two games, but they still own a 17.3 points per game differential.

Clemson is still the favorite, but the underdogs are getting more bets. The total has dropped to 44 or 44.5 at most sportsbooks.

Clemson vs. Notre Dame is a college football game in which the Tigers are favored.

Notre Dame is favored by 110 points over Clemson. The Tigers are ranked No. 4 in the CFP rankings, but their strength of schedule is 72nd. High winds are forecasted for Saturday. Notre Dame has recorded 200-plus rushing yards in four of their last five games.

Clemson has scored on all but one of its 39 red-zone drives. Notre Dame has allowed points on 100% of opponents' red zone possessions. The Under is 5-1-0 during Clemson's last seven non-conference games.

Shipley is the ACC's third-best rusher at 739 yards. Notre Dame has held opponents under 300 yards in consecutive weeks. Clemson quarterback D.J. Uiagalelei has been struggling since being benched in Week 9.

Clemson vs. Notre Dame is a college football game on 11/4/2022 at 6:18 a.m. ET.