49ers vs. Cardinals Picks, Predictions Week 11: Will Arizona’s Injury Concerns Play a Role?

The San Francisco 49ers play in their second consecutive primetime game in Mexico City. The NFL has added games in Azteca Stadium in an effort to grow the game globally. This is the fifth time the NFL games have been played in this venue. Arizona swept the season series against San. Francisco last year by a combined score of 48-27.

The 49ers are 7.5-point favorites against the Cardinals. The total has not budged from its opening number of 43.

49ers are the favorites at pointsbet with -8. Arizona is 10-4 straight up since the start of last season with DeAndre Hopkins in the starting lineup. Kyler Murray is a game-time decision with a hamstring injury, and Colt McCoy and were limited in practice this week.

The 49ers have held seven of their nine opponents to 19 or fewer points. The Cardinals offense has averaged 29 points per game over the last four games. James Conner is coming off a two-touchdown performance.

Hopkins has 10-plus catches in three of four games played this season. He has 46 targets in four matches this year. Hopkins is a good bet to score a touchdown.

49ers vs. Cardinals is a game on 11/20/22 at 6:57 a.m. ET.