DeAndre Hopkins, Christian McCaffrey and Brandon Aiyuk Best Prop Bets and Odds for Monday Night Football

The Cardinals and 49ers meet for the first time this season on Monday night at Estadio Azteca in Mexico City. Arizona can claw its way back into the playoff picture with a victory. San Francisco goes for its third consecutive win and looks to gain ground on the division-leading Seahawks.

DeAndre Hopkins is back from suspension and has four red zone targets and two touchdowns in four games. He has been targeted 11.5 times per game. Last week he caught 10 of 14 targets for 98 yards but didn't score. The 49ers are weaker against the pass than the run. Hopkins has the fourth-best odds to score in this game, but he's questionable with a hamstring injury.

Christian McCaffrey is under-65 rushing yards (-125) for Monday Night Football against Arizona. He has only topped this total once since joining the 49ers. Last week he rushed for 38 yards against the Chargers.

Brandon Aiyuk is over 55.5 Receiving Yards in his last five games. He's cleared this mark by 25-plus yards in each of his the last four games, and he's had six or more targets in four of those games after only seeing that many passes twice in the first five. Arizona has a bottom-10 pass defense and is also down Byron Murphy Jr.