Week 6 NFL picks, odds, 2023 best bets from advanced model: This 5-way football parlay pays out 25-1
Matthew Stafford and the Los Angeles Rams are off to a 2-3 start and will now host the Arizona Cardinals for a divisional showdown in Week 6. The Rams have lost nine of their last 10 games against opponents from the NFC, but Los Angeles is 11-2 in its last 13 meetings with the Cardinals. According to the latest Week 6 NFL odds from the SportsLine consensus, the Rams are favored by seven points at home on Sunday. Should your Week 6 NFL picks include backing the Rams to cover one of the largest NFL spreads this week, or are you better off targeting another favorite like the Lions (-3) on the road against the Buccaneers? Before you make any Week 6 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2023 NFL season on an incredible 171-119 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 25-11 roll on top-rated NFL picks since Week 7 of last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has locked in five confident NFL best bets for Week 6. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 6 NFL picks at SportsLine.
Top Week 6 NFL picks
After simulating every game 10,000 times, the model is high on the San Francisco 49ers (-7) to cover on the road against the Cleveland Browns. Cleveland's defense is among the league's best, but the 49ers have the offensive weapons to exploit the Browns on Sunday.
Running back Christian McCaffrey has found the end zone in his last 14 games with the 49ers, while quarterback Brock Purdy has yet to throw an interception this season. Tight end George Kittle scored three touchdowns in last week's victory over the Cowboys, and wide receiver Deebo Samuel has racked up over 100 all-purpose yards in two of his last three games. Defensively, the 49ers are giving up just 13.6 points per game, a major reason why San Francisco covers the spread in nearly 60% of simulations. See which other NFL parlay picks to make here.
How to make Week 6 NFL parlays
The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that wins outright. You can only see the model's NFL Week 6 best bets and parlay at SportsLine.
What are the model's top Week 6 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 6 NFL best bets from a model on a 171-119 run on top-rated picks, and find out.
