Week 8 NFL picks, odds, 2022 best bets from advanced model: This 5-way football parlay returns 25-1

The San Francisco 49ers are 1.5-point favorites against the Los Angeles Rams in the latest NFL odds at Caesars Sportsbook. The 49er's new running back Christian McCaffrey had his first full week of practice with his new team. Los Angles Rams are 3-3 and need to contain McCafrey and Deebo Samuel. SportsLine's advanced computer model simulates every NFL game 10,000 times and has returned a profitable 148-107 on top-rated NFL picks since 2017.

Buffalo Bills are covering the spread against the Green Bay Packers. Green GB lost to Washington Commanders last Sunday and to the Jets the week before. Buffalo Bills have a better running game than Green Bags.

The model also has a 5-way football parlay that returns 25-1. It also backs an underdog that will win outright in four other NFL games.