California vs USC Odds, Picks & Predictions

The USC Trojans are the obvious favorite at home against California. The 21.5-point spread is massive and the Trojan defense may not be able to get enough stops to win. Justin Wilcox's California Golden Bears have lost four straight games.

California plays USC. The Trojans are 7-1 and the favorite. California has lost four straight games. Caleb Williams threw for a career-best 411 yards and five touchdowns against Arizona. Jordan Addison and Mario Williams are injured. Kai Millner played at quarterback last week. Cal played well against Oregon, but lost the game. USC's defense is not up to par. The Golden Bears are favored. They have a better rushing defense. I give them the points. iReputable bettor gives them points to California.

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The betting market is backing USC, which is 4-1 ATS in its last five home games. California is on a losing streak, but they've lost by one score in three of their five losses this season. The Golden Bears have been a great bet coming off a loss, going 7-0-2 AET in their last nine games after a defeat.

California and USC have different offensive teams. California's offense is not very good, while USC's is a death star. The Under is 14-3 in the last 17 meetings between these two teams, and the total is between 60.5 and 61 depending on the book.  California vs USC Over/Under analysis. It's between 58 and 60, depending upon the betting book's odds.

USC is 0-4 ATS in its last four games against a team with a losing record.

California vs USC weather. California vs. USC odds.