Colts vs. Titans Predictions, Picks, Odds Week 13

Our Indianapolis Colts vs. Tennessee Titans predictions are based on the best NFL odds at our best sports betting apps a solid day for Titans running back Derrick Henry against a generous Indy run defense.

With the Indianapolis Colts (6-5) suddenly above .500 and in the mix for a playoff spot behind a Colts quarterback Gardner Minshew-led three-game winning streak, the Tennessee Titans (4-7) have their work cut out for them at home in Week 13. 

Could Tennessee's key to success be found relying on old-school football with running back Derrick Henry leading the charge?

In addition to ourNFL Week 13 predictions and NFL Week 13 player props here are our best Colts vs. Titans prediction and our NFL picks (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

Colts vs. Titans prediction

Derrick Henry Over 60.5 rushing yards (-114 via FanDuel) ⭐⭐⭐⭐

Although the game-time temperature in Nashville could reach an unseasonably warm 60 degrees for kickoff between the Colts and Titans, the cold-weather months tend to be when Derrick Henry has historically become a battering ram for the Tennessee offense.

This week against Indianapolis, Henry should be primed for a solid output given the matchup against a soft run defense combined with the reality of relative struggles for the Titan passing offense. The Colts have allowed an average of 129.3 rushing yards per game this season, which ranks 26th in the NFL.

As Titans quarterback Will Levis hasn’t cleared 200 passing yards in any of his past three games, it seems the primary method of matriculation downfield for Tennessee will be hoping that Henry churns out consistent yardage.

While Henry has had more dud games than usual in his age-29 season, he’s still cleared this attainable rushing line seven times on the year, including in four of his last six games.

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Colts vs. Titans best odds

FanDuel: Henry Over 60.5 rushing yards (-114) 

DraftKings offers poor value for this prop as their odds are watered down to -125. Caesars isn’t much better, offering -119 odds on Over for the same rushing total. BetMGM and bet365 offer -110 odds on Henry, clearing 62.5 yards, making both sportsbooks quality options for this prop.

Our top recommendation is FanDuel, which offers a better line on Henry’s rushing total at 60.5 yards. At -114 odds, that’s a negligible difference to gain multiple yards on the line.

Colts vs. Titans odds

The Titans opened as a one-point favorite but have seen the line shift at our best sports betting apps. The Colts are now favored by between one and two points across our best sportsbooksas 69% of wagers have come in on Indianapolis.

The total opened at 41.5 and has increased to between 42.5 and 43 across our best sportsbooks despite 57% of the total wagers coming in on Under. We’re likely getting some sharp money on the Over to have moved the line in that direction.

Colts vs. Titans game info

• When:Sunday, Dec. 3, at 1:00 p.m. ET
• Where:Nissan Stadium, Nashville, TN
• How to watch:CBS
• Weather:60 Degrees, 12 mph Winds, 7 Precipitation

Colts-Titans prediction made Friday at 11:45 a.m. ET

NFL betting odds pages

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