Week 15 NFL picks, odds, 2022 best bets from advanced model: This 5-way football parlay would pay out 25-1

Week 15 NFL picks, odds, and parlays from advanced model: This 5-way football parlay would pay out 25-1. Tua Tagovailoa and the Miami Dolphins take on Josh Allen and Buffalo Bills on Saturday. The Dolphins have lost two games in a row, while the Bills have won four in row. Buffalo is 7.5-point favorites in the latest NFL odds at Caesars Sportsbook. SportsLine's model simulates every NFL game 10,000 times and is up more than $7,100 for $100 players on top-rated NFL bets since its inception.

The advanced model simulates every NFL game 10,000 times and it's high on the Dallas Cowboys to cover against the Jacksonville Jaguars. The Jaguars have one of the worst passing defenses in the league.

The advanced model predicts a 25-1 parlay for the NFL's Week 15 best bets. It also has a pair of underdogs that have a chance to win outright.