Week 17 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay pays out 25-1

The Miami Dolphins are without starting quarterback Tua Tagovailoa. Teddy Bridgewater will start for Miami against the New England Patriots. The Patriots are 3-point favorites in the latest Week 17 NFL odds at Caesars Sportsbook. SportsLine's advanced computer model simulates every NFL game 10,000 times and has made some impressive bets in recent years. It has produced a 25-1 payout for parlaying five NFL best bets for Week17.

The advanced model simulates every NFL game 10,000 times and it's high on the San Francisco 49ers to cover against the Las Vegas Raiders. The Raiders allow the sixth-worst offense through the air per game. 49er quarterback Brock Purdy has been throwing for more than 200 yards in three of his four appearances since Jimmy Garoppolo's injury. Brandon Aiyuk and George Kittle should get fed early and often in this game, while the 49erns are covering the spread in more more that 50% of simulations.

The advanced model predicts a 25-1 payout for a parlay with NFL Week 17 best bets. It also has a pair of underdogs that have a chance to win outright.