Week 5 NFL picks, odds, 2022 best bets from advanced model: This 5-way football parlay pays 25-1

The New York Giants take on the Green Bay Packers in London for the second straight week. The Giants won both of their previous regular-season games in England. Greenbay is seeking its fourth straight victory after opening the 2022 season with a loss at Minnesota. SportsLine's computer model simulates every NFL game 10,000 times and has made 139-103 straight-up NFL picks since 2017. It beat 94% of CBS Sports Football Pick'em players four times in a row.

The model simulates every game 10,000 times and it's picking the Miami Dolphins to win and cover against the New York Jets on Sunday. Miami has a 56-55-1 advantage in the all-time series between the AFC East rivals. The Dolphins have dominated of late, winning four straight meetings and 10 of the last 12.

The advanced model predicts a 25-1 parlay for the NFL's Week 5. It also has a model that backs an underdog to win outright.