Houston vs. Memphis prediction, odds, spread: 2022 Week 6 college football picks, best bets from proven model

Memphis Tigers host Houston Cougars at Liberty Bowl Memorial Stadium on Friday at 7:30 p.m. ET. Memphis is 4-1 overall and 2-0 in conference, riding a four-game winning streak. Houston is 2.3 overall, 0- 1 in AAC play after a 27-24 loss to Tulane. Caesars Sportsbook lists Memphis as 2,5-point home favorites. The over/under is 57.5 in the latest Houston vs.Memphians odds.

Houston vs. Memphis is a college football game in 2022. The money line is Memphis -155, Houston +135. Houston is 1-4 against the spread in the last four years.

Houston and Memphis are playing each other. The Cougars are 1-4 against the spread in 2022. Memphis is 2-3 against a spread this season.

Houston has the third-most sacks in the AAC this season. Memphis has given up 15 sacks. Houston is also capable of scoring 30.6 points per game. The Cougars are elite on third down. Nathaniel Dell is in top five of the conference in receptions (33), receiving yards (453), and he has five touchdown catches in 2022.

Memphis is 4-1 and 2-0 in conference play. The Tigers are averaging 402.4 yards per game and 34.3 points per contest. Memphis has nine touchdown passes and only one interception this season. Houston is also struggling on defense, giving up 34 points a game.

SportsLine's model is leaning Over on the point total. Both teams are projected to exceed 285 passing yards. One side of the spread hits in more than 50% of simulations.