Rams vs. Saints odds, line, spread: 2022 NFL picks, Week 11 predictions from proven computer model

The Los Angeles Rams are on a three-game losing streak. New Orleans has won two of its last nine games. The Rams won the last meeting 27-9 in 2019. Kickoff is set for 1 p.m. ET. SportsLine's advanced computer model simulates every NFL game 10,000 times and has returned over $7,500 for $100 players on top-rated NFL picks since its inception.

SportsLine's computer model has set its sights on Saints vs. Rams. The model is using a model that has a very high level of accuracy.

Saints vs. Rams money line is New Orleans -150, Los Angeles -126. Saints vs Rams over/under is 39 points.

The Saints are coming off back-to-back double-digit losses to Baltimore and Pittsburgh. New Orleans has had as many as 10 players miss practice this week. Los Angeles is expected to have Matthew Stafford back under center after he missed last week's game with a concussion. The Rams have won five of the last seven games between these teams and covered in eight of last 11.

Rams are without several starters along the offensive line and without star wide receiver Cooper Kupp. New Orleans is without a star player, but Stafford is expected to play. Rams have only covered the spread twice in their last 11 games.

The model simulates Rams vs. Saints 10,000 times and it's leaning Over.