Week 13 NFL picks, odds, 2022 best bets from advanced model: This 5-way football parlay pays 25-1

Washington Commanders are a 1.5-point favorite against New York Giants in the Week 13 NFL schedule. Washington has won six of its last seven games. New Yorkers have lost three of their last four games this season. SportsLine's advanced computer model simulates every NFL game 10,000 times and has returned over $7,500 for $100 players on top-rated NFL picks since its inception.

The model simulates every game 10,000 times and it's picking the San Francisco 49ers to cover the spread against the Miami Dolphins. San Francians are on a four-game winning streak and have won three of their last four games by at least 13 points. Miami is on its own on an impressive winning run, but it hasn't been on the road since the first week of November.

The advanced model predicts a 5-way football parlay that pays 25-1. It also has a pair of underdogs that are projected to win outright.