College Football

Clemson vs. Louisville prediction: College football picks, odds

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Clemson vs. Louisville prediction: College football picks, odds

Clemson is a touchdown favorite against Louisville in the ACC on Saturday. The Tigers have won three games in three weeks. They beat Florida State and Syracuse.

Clemson's starting quarterback DJ Uiagalelei hasn't been very good. Louisville has four consecutive wins by at least 14 points. Dynamic QB Malik Cunningham has been at the forefront.

Clemson's offense has struggled recently with Uiagalelei at the helm. Beaux Collins has been injured.

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