No. 5 Clemson at Notre Dame odds preview: Spread, prediction for Tigers vs. Fighting Irish

Clemson Tigers and the Notre Dame Fighting Irish will play each other on Saturday at Notre Notre Irish Stadium. Clemson is the favorite as they are aiming to return to the College Football Playoff. Notre Ireland is coming off a 41-24 victory over Syracuse. Caesars Sportsbook is giving Clemson a 4.5-point road favorite.

No. 5 Clemson plays at Notre Dame at 7:30 p.m. ET on NBC.

No. 5 Clemson is favored by 4.5 points at Caesars Sportsbook.

No. 5 Clemson is playing at Notre Dame. The line is Clemson -195 and Notre Notre Irish -162.

No. 5 Clemson is a 3-point favorite against the Fighting Irish. The Tigers have a 66% chance of winning and staying undefeated. Notre Dame is 4-4 against spread this season. Clemson's quarterback situation remains in flux. The team's defense gives up 19.9 points per game.

No. 5 Clemson is playing at Notre Dame.